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No lethal dose has been established, and animal models show a very high safety threshold

Considering that mice show ~7-fold higher metabolic turnover, this in vivo study represents a treatment model that is achievable for the treatment of patients with NSCLC in the clinic

J Neurosci 18(6):21612173

Esophageal Stricture: Narrowing of the esophagus due to scar tissue, which can cause difficulty swallowing

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Because so much of GHK-Cus activity is copper-mediated, it is difficult in some experiments to separate specific tripeptide signaling from generic copper effects a point made concrete by the finding that the MMP-2 effect was reproduced by copper ions alone while the collagen-synthesis effect required the intact peptide